The combination of Dapagliflozin 10 mg and Metformin Hydrochloride 500 mg Extended Release (ER) tablets is a prescription medication used primarily to treat Type 2 diabetes mellitus. It is also used to lower the risk of cardiovascular death and hospitalization for heart failure in certain patients, and the risk of worsening kidney disease. 
Key Information
  • Uses:
    • Manages high blood sugar levels in adults with type 2 diabetes, when diet and exercise alone are not sufficient.
    • Lowers the risk of hospitalization for heart failure in type 2 diabetes patients with established cardiovascular disease.
    • Reduces the risk of worsening chronic kidney disease.
  • Mechanism of Action:
    • Dapagliflozin (an SGLT2 inhibitor) works by helping the kidneys remove excess glucose from the body through urine.
    • Metformin (a biguanide) works by decreasing glucose production in the liver, reducing sugar absorption from the stomach/intestines, and increasing the body’s sensitivity to insulin.
  • Dosage & Administration:
    • This medication is typically taken orally once daily in the morning with food.
    • The tablet must be swallowed whole and never crushed, cut, or chewed, as it is an extended-release formula.
    • The exact dosage and treatment plan should be determined by a healthcare professional based on individual needs and kidney function.
  • Common Side Effects:
    • Urinary tract infections (UTIs)
    • Genital fungal infections
    • Sore throat, stuffy or runny nose
    • Nausea, vomiting, diarrhea, stomach pain
    • Headache
  • Serious Warnings:
    • Lactic Acidosis: A rare but serious condition that can occur with metformin, especially with excessive alcohol intake or kidney problems. Symptoms include unusual muscle pain, trouble breathing, and stomach pain.
    • Ketoacidosis: A serious condition with dapagliflozin. Symptoms include nausea, vomiting, stomach pain, and difficulty breathing. 
Always consult a doctor or pharmacist for personalized medical advice, especially if you have existing kidney or liver conditions, or are pregnant or breastfeeding. This medicine is part of a comprehensive treatment program that should also include a healthy diet and regular exercise. 

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