Doxofylline 400 mg is a prescription bronchodilator tablet used to treat and prevent symptoms of asthma and Chronic Obstructive Pulmonary Disease (COPD). It works by relaxing and widening the airways in the lungs, making breathing easier. 
Key Information
  • Uses:
    • Asthma
    • Chronic Obstructive Pulmonary Disease (COPD), which includes chronic bronchitis and emphysema
    • Bronchospasm (tightening of airways)
  • Mechanism of Action: Doxofylline inhibits phosphodiesterase enzymes, which relaxes the smooth muscles of the airways and widens the air passages. It is not a steroid or an antibiotic.
  • Important Note: This medication does not work immediately for sudden breathing problems. You should always carry a fast-acting (rescue) inhaler for emergencies. 
Usage and Dosage
  • Administration: Take the tablet as a whole with a glass of water. Do not chew, crush, or break it.
  • Timing: It can be taken with or without food, but taking it at a fixed time each day (preferably in the evening) is recommended for consistency.
  • Duration: Use it for the dose and duration prescribed by your doctor. Do not stop taking it without consulting your doctor, even if you feel better.
  • Typical Dose: A common adult dose is one 400 mg tablet twice a day, or as advised by a doctor. The dosage may be adjusted based on the patient’s condition. 
Common Side Effects
Most side effects are temporary and typically resolve as your body adjusts to the medicine. 
  • Headache
  • Nausea and vomiting
  • Stomach upset or pain
  • Irritability or restlessness
  • Difficulty sleeping (insomnia)
  • Fast or irregular heart rate 
Important Precautions and Warnings
  • Medical History: Inform your doctor if you have kidney, liver, or heart problems (including low blood pressure or a recent heart attack), an overactive thyroid, or stomach ulcers.
  • Interactions: Avoid consuming high-caffeinated products like coffee, tea, and dark chocolate, as they can enhance the drug’s side effects. This medication may also interact with other medicines, so tell your doctor about all current medications you are taking.
  • Pregnancy and Breastfeeding: Consult your doctor if you are pregnant or planning a pregnancy. Doxofylline is generally not recommended during breastfeeding.
  • Smoking/Alcohol: Avoid smoking while on this treatment as it can reduce the medicine’s effectiveness. Consult your doctor regarding alcohol consumption. 
For more specific advice on the use, dosage, and potential interactions, consult your healthcare provider.

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