Gliclazide 80 mg + Metformin 500 mg tablets are a combination prescription medication used to treat Type 2 diabetes mellitus in adults. This medicine helps control blood sugar levels when diet, exercise, and single-drug therapy alone are not enough. 
Key Information
Active Ingredients Gliclazide (80 mg) and Metformin Hydrochloride (500 mg)
Drug Class Anti-diabetic drugs (Gliclazide is a sulfonylurea; Metformin is a biguanide)
Mechanism of Action Gliclazide stimulates the pancreas to release more insulin. Metformin reduces glucose production in the liver and improves the body’s sensitivity to insulin.
Primary Use Management of Type 2 diabetes mellitus in adults.
Administration Taken orally with food to reduce stomach upset. Swallow the tablet whole; do not chew or crush it.
Important Precautions
  • Prescription Only: This medication should be used strictly under medical supervision.
  • Hypoglycemia: Low blood sugar (hypoglycemia) is a common side effect. You should know the symptoms (sweating, dizziness, headache, hunger, shaking) and carry a fast-acting source of glucose (like sugary food or fruit juice).
  • Alcohol: Avoid alcohol consumption, as it increases the risk of hypoglycemia and a rare but serious condition called lactic acidosis.
  • Contraindications: Not for use in Type 1 diabetes, diabetic ketoacidosis, or severe kidney or liver disease.
  • Pregnancy/Breastfeeding: Consult your doctor if pregnant or breastfeeding, as it may be unsafe.
  • Regular Monitoring: Regular monitoring of blood sugar levels, kidney function, and liver function is important during treatment. 
Common Side Effects
Most side effects are temporary as your body adjusts to the medicine. 
  • Hypoglycemia (low blood sugar level)
  • Nausea and vomiting
  • Diarrhea and stomach pain
  • Headache
  • Taste changes 
For comprehensive information, always refer to the patient information leaflet provided with the medication or consult with a healthcare professional. 

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