The tablet containing Glimepiride 0.5 mg and Metformin 500 mg SR (Sustained Release) is a prescription medicine used to treat Type 2 diabetes mellitus in adults. It is a combination of two anti-diabetic drugs that help control blood sugar levels when diet and exercise alone are insufficient. 
Key Information
  • Active Ingredients & Function:
    • Glimepiride (0.5 mg): A sulfonylurea that stimulates the pancreas to produce and release more insulin.
    • Metformin SR (500 mg): A biguanide that reduces the amount of glucose produced by the liver, delays sugar absorption from the intestines, and improves the body’s sensitivity to insulin.
  • Usage:
    • Treatment of Type 2 diabetes mellitus.
    • Used as an adjunct to a healthy diet, regular exercise, and weight reduction program.
    • Not indicated for Type 1 diabetes or diabetic ketoacidosis.
  • Administration:
    • Take orally with food to reduce stomach upset.
    • Swallow the tablet whole; do not chew, crush, or break it (due to the sustained-release formulation).
    • Take it regularly at the same time each day for the best results.
    • Dosage is determined by your doctor and may be adjusted based on your blood sugar levels. 
Potential Side Effects and Precautions
  • Hypoglycemia (Low Blood Sugar): The most common side effect. Symptoms include sweating, dizziness, headache, hunger, and shakiness. Always carry a fast-acting source of glucose (e.g., fruit juice, candy) to treat this.
  • Lactic Acidosis: A rare but serious condition associated with metformin, especially in people with kidney disease or those who consume excessive alcohol. Symptoms include muscle pain, difficulty breathing, nausea, vomiting, and stomach pain; seek immediate medical attention if these occur.
  • Other Common Side Effects: Nausea, diarrhea, stomach pain, headache, and a metallic taste in the mouth.
  • Alcohol: Avoid alcohol consumption as it increases the risk of low blood sugar and lactic acidosis.
  • Pregnancy/Breastfeeding/Medical Conditions: Consult your doctor if you are pregnant, breastfeeding, or have kidney, liver, or heart problems. 
Always consult a healthcare professional for personalized medical advice regarding your condition and treatment options. 

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