The tablet containing Glimepiride 1 mg, Pioglitazone 15 mg, and Metformin Hydrochloride 500 mg (Extended Release/Sustained Release – ER/SR) is a combination medicine used to manage Type 2 diabetes mellitus. 
Key Information
  • Primary Use: This medicine is prescribed to control high blood sugar levels in adults with Type 2 diabetes, particularly when diet, exercise, and single-agent medications (monotherapy) have not provided adequate control.
  • Mechanism of Action:
    • Glimepiride stimulates the pancreas to release more insulin.
    • Metformin reduces glucose production in the liver, delays glucose absorption from the intestines, and increases the body’s sensitivity to insulin.
    • Pioglitazone further enhances the sensitivity of muscle, fat, and liver cells to insulin, enabling more effective glucose removal from the blood.
  • Administration: It should be taken orally, typically once or twice daily, with food to minimize stomach upset. The tablet should be swallowed whole; do not crush, chew, or break the extended-release formulation.
  • Important Precautions:
    • Hypoglycemia (low blood sugar): This is a common side effect, especially if meals are skipped, alcohol is consumed, or excessive exercise is done. Always carry a quick source of sugar (e.g., candy, fruit juice).
    • Alcohol: Avoid alcohol consumption as it increases the risk of lactic acidosis, a rare but serious condition.
    • Medical Conditions: Inform your doctor about any kidney, liver, or heart problems, or a history of bladder cancer, before starting this medication.
    • Pregnancy/Breastfeeding: This medicine is generally not recommended during pregnancy or breastfeeding; consult a doctor. 
Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a healthcare professional for diagnosis and treatment of medical conditions. 

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