Metolazone IP 2.5 mg tablets contain metolazone, a potent thiazide-like diuretic (water pill) used to treat high blood pressure and fluid retention (edema) caused by conditions such as heart failure, kidney disease, or liver disease. It is a prescription-only medication. 
Key Information
  • Active Ingredient: Metolazone 2.5 mg.
  • Mechanism of Action: Metolazone works by helping your kidneys eliminate excess salt (sodium) and water from the body through increased urine production, which in turn lowers blood pressure and reduces swelling.
  • Uses:
    • Hypertension (high blood pressure).
    • Edema (fluid retention/swelling) associated with congestive heart failure, kidney disorders (including nephrotic syndrome), or liver disease.
  • Administration: It is typically taken orally once a day, preferably in the morning with or after food, to avoid frequent nighttime urination. The tablet should be swallowed whole. 
Important Precautions and Side Effects
  • Medical Supervision: This medication requires a doctor’s prescription and regular monitoring of kidney function and electrolyte levels (such as sodium and potassium) through blood tests.
  • Common Side Effects: Dizziness, lightheadedness, headache, nausea, blurred vision, muscle weakness or cramps, and tiredness are common.
  • Serious Side Effects: Can cause severe electrolyte imbalances (dangerously low sodium or potassium levels), liver damage, or severe skin reactions. Seek immediate medical attention if you experience symptoms like irregular heartbeats, confusion, severe weakness, or a spreading skin rash.
  • Lifestyle:
    • Avoid driving or operating machinery until you know how the drug affects you, as it can cause dizziness.
    • Use alcohol with caution, as it may increase dizziness.
    • It may make your skin more sensitive to the sun; use sun protection.
  • Contraindications: Do not take if you are unable to pass urine (anuria), have severe liver disease, or are allergic to metolazone or sulfa drugs. 
Always consult with a healthcare professional or pharmacist regarding your specific condition and any potential interactions with other medications you may be taking.

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