The Pregalin M SR 75 tablet is a prescription medicine containing Pregabalin (75mg) and Methylcobalamin (1500mcg), primarily used to treat neuropathic pain (nerve pain). It is a sustained-release (SR) formulation, meaning it is designed to work over an extended period. 
Key Information
  • Active Ingredients: Each tablet contains Pregabalin 75 mg (sustained-release form) and Methylcobalamin 1500 mcg.
  • Manufacturer: It is manufactured by Torrent Pharmaceuticals Ltd..
  • Uses: It is used to manage long-lasting pain caused by nerve damage due to conditions such as diabetes (diabetic neuropathy), shingles (post-herpetic neuralgia), or spinal cord injury. It helps reduce associated symptoms like mood changes, sleep problems, and tiredness.
  • Mechanism of Action: Pregabalin works as an anticonvulsant that reduces pain signals by modulating calcium channel activity in nerve cells. Methylcobalamin (Vitamin B12) helps produce myelin, a substance that protects and rejuvenates damaged nerve fibers. 
Important Considerations and Side Effects
  • Usage: The tablet should be swallowed whole with water, with or without food, preferably at bedtime, as advised by your doctor. It should not be crushed, chewed, or broken.
  • Do not stop suddenly: Abruptly stopping this medication can cause withdrawal symptoms like anxiety, difficulty sleeping, nausea, and sweating. The dosage should be gradually reduced under a doctor’s supervision.
  • Common Side Effects:
    • Dizziness and drowsiness
    • Headache
    • Nausea, vomiting, diarrhea, or constipation
    • Blurred vision
    • Increased appetite and weight gain
    • Fatigue and impaired coordination
  • Precautions:
    • Alcohol should be avoided as it can increase sleepiness and dizziness.
    • Driving or operating machinery is not recommended until you know how the medicine affects you due to potential dizziness and sleepiness.
    • Consult your doctor if you are pregnant or breastfeeding, or have existing kidney, liver, or heart problems.
    • Monitor for unusual mood or behavior changes, including suicidal thoughts, and inform your doctor immediately if they occur. 

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