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Sacubitril 24 mg + Valsartan 26 mg Tabs (Swasartan 24/26) – GA
₹185.00
The tablet containing Sacubitril 24 mg + Valsartan 26 mg is a prescription medication primarily used to treat heart failure. It is an angiotensin receptor-neprilysin inhibitor (ARNI) combination drug.
Key Information
- Primary Use: Treatment of chronic heart failure with reduced ejection fraction (HFrEF) in adults and children (one year of age and older). It helps reduce the risk of cardiovascular death and hospitalization.
- Mechanism of Action: The combination works in two complementary ways:
- Sacubitril: Inhibits the enzyme neprilysin, increasing the levels of beneficial natural peptides (like natriuretic peptides) that help widen blood vessels and reduce fluid and sodium retention.
- Valsartan: An angiotensin II receptor blocker (ARB) that prevents the hormone angiotensin II from constricting blood vessels, thereby lowering blood pressure and reducing the heart’s workload.
- Dosage: The 24 mg sacubitril and 26 mg valsartan tablet (often referred to as 50 mg total dose) is typically a starting dose, particularly for patients not currently taking an ACE inhibitor or ARB, or those with moderate liver or severe kidney impairment. The dose is usually increased gradually by a doctor to a target maintenance dose.
- Administration: The tablet should be swallowed whole with or without food, usually twice daily at the same time each day. Do not crush or chew the tablet.
- Monitoring: Regular monitoring of blood pressure, kidney function, and potassium levels is essential during treatment.
Important Cautions and Warnings
- Pregnancy and Breastfeeding: This medication is not recommended during pregnancy (especially the second and third trimesters) as it can cause harm or death to the fetus, and it is likely unsafe while breastfeeding.
- Drug Interactions: It must not be taken within 36 hours before or after taking an Angiotensin-Converting Enzyme (ACE) inhibitor (e.g., enalapril, lisinopril) due to a significantly increased risk of a severe allergic reaction called angioedema (swelling of the face, lips, tongue, or throat).
- Kidney/Liver Disease: Use with caution in patients with kidney or liver disease; dose adjustments may be necessary. It is contraindicated in patients with severe liver impairment.
- Potassium Levels: It may raise potassium levels in the blood (hyperkalemia). Avoid taking potassium supplements or high-potassium foods without consulting your doctor.
- Dizziness: Dizziness or lightheadedness, particularly when standing up, is a common side effect. Patients should rise slowly from a sitting or lying position.
Common Side Effects
- Low blood pressure (hypotension)
- High potassium levels in the blood (hyperkalemia)
- Cough
- Dizziness
- Impaired kidney function
- Fatigue
Always consult a healthcare professional for advice regarding this medication, as its use and dosage depend entirely on an individual’s specific medical condition and needs.
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