FLAGYL-400 (Metronidazole 400mg) is an antibiotic and antiprotozoal medication used to treat various infections of the blood, brain, lungs, bones, stomach, intestines, and genital tract. It is a prescription drug and should only be used as directed by a doctor. 
Key Information
  • Active Ingredient: Metronidazole 400mg.
  • Manufacturer: Abbott India Ltd..
  • Mechanism of Action: It works by stopping the growth of infection-causing bacteria and parasites by damaging their DNA, leading to their death.
  • Administration: It should be swallowed whole with a glass of water, ideally with food to avoid stomach upset, and taken at the same time each day for optimal results.
  • Important Precautions:
    • Do not stop taking the medication early, even if symptoms improve, to ensure complete eradication of the infection and prevent resistance.
    • Avoid all alcohol consumption during treatment and for at least 48 hours after finishing the course, as it can cause unpleasant side effects like nausea, vomiting, and stomach pain (disulfiram-like reaction).
    • Inform your doctor if you have liver or kidney problems, nervous system disorders, are pregnant, or breastfeeding. 
Common Uses
FLAGYL-400 is used to manage a wide range of bacterial and parasitic infections: 
  • Bacterial Infections: Treats infections caused by anaerobic bacteria in the blood, brain, lungs, bones, joints, skin, soft tissues, stomach lining, pelvic area, intestines, gums, and teeth.
  • Parasitic Infections: Effective against protozoan parasites causing conditions like amoebiasis (amoebic dysentery), giardiasis, and trichomoniasis (a genital tract infection).
  • Other Applications: Used in combination therapy for stomach ulcers caused by Helicobacter pylori and to prevent infections after surgery or childbirth. 
Potential Side Effects
Most side effects are generally mild and temporary, resolving as the body adjusts to the medication. 
  • Common Side Effects:
    • Headache.
    • Nausea and vomiting.
    • Dry mouth and a metallic taste.
    • Loss of appetite and stomach cramps/pain.
    • Dizziness.
  • When to Consult a Doctor Immediately:
    • Signs of a severe allergic reaction (rash, itching, swelling of the face/throat, difficulty breathing).
    • Severe skin reactions (blistering, peeling, fever).
    • Nerve problems such as numbness, tingling, pain in hands or feet, or loss of coordination.
    • Yellowing of the skin or eyes (jaundice). 

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