Metformin Hydrochloride 500 mg SR (Sustained Release) tablets are a type 2 diabetes medication also used to treat Polycystic Ovary Syndrome (PCOS). It works by helping your body use insulin more effectively and reducing the amount of sugar produced by the liver. 
Key Information
  • Primary Uses: Metformin Hydrochloride 500 mg SR is primarily used to manage type 2 diabetes mellitus and Polycystic Ovarian Syndrome (PCOS).
  • Administration: The tablet is for oral use and should be swallowed whole with or after food to minimize stomach discomfort; it should not be crushed, broken, or chewed. It is typically taken once or twice daily, as advised by a doctor.
  • Mechanism: As a biguanide anti-diabetic agent, it lowers blood glucose by decreasing glucose production in the liver, delaying intestinal absorption of glucose, and increasing insulin sensitivity. 
Common Side Effects
Most side effects are generally temporary and tend to disappear as your body adjusts to the medication. 
  • Diarrhea
  • Nausea and vomiting
  • Abdominal or stomach discomfort/pain
  • Loss of appetite
  • Metallic taste in the mouth
  • Headache
  • Vitamin B12 deficiency with long-term use 
Serious Warnings
  • Lactic Acidosis: This is a rare but serious medical condition involving a buildup of lactic acid in the blood. Seek immediate medical attention if you experience symptoms like deep or rapid breathing, persistent nausea, vomiting, severe stomach pain, muscle cramps, or unusual tiredness.
  • Alcohol Consumption: Avoid excessive alcohol intake, as it significantly increases the risk of lactic acidosis and severe low blood sugar (hypoglycemia).
  • Kidney Function: Metformin is not recommended for patients with severe kidney disease. Your doctor will monitor your kidney function regularly while you are on this medication. 
Lifestyle & Dietary Advice
  • Diet and Exercise: This medication works best when combined with a healthy diet and a regular exercise program.
  • Hydration: Drink plenty of water, especially if you experience diarrhea or vomiting, to prevent dehydration.
  • Blood Sugar Monitoring: Regularly monitor your blood sugar levels as instructed by your doctor. 

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