The combination of Sitagliptin Phosphate 100 mg + Dapagliflozin 10 mg is a prescription medication used, along with diet and exercise, to manage type 2 diabetes mellitus in adults. It works through two complementary mechanisms to control blood sugar levels and may offer additional cardiovascular and renal benefits. 
Key Information
  • Primary Use: Treatment of type 2 diabetes mellitus to improve glycemic control and reduce the risk of long-term complications such as kidney damage, blindness, nerve problems, heart attack, and heart failure.
  • Mechanism of Action:
    • Sitagliptin (100 mg): A dipeptidyl peptidase-4 (DPP-4) inhibitor that increases insulin production after meals and decreases the amount of glucose produced by the liver.
    • Dapagliflozin (10 mg): A sodium-glucose cotransporter 2 (SGLT2) inhibitor that helps the kidneys remove excess sugar from the body through urine.
  • Administration: It is typically taken orally once a day, with or without food, as directed by a healthcare professional. The tablet should be swallowed whole; do not crush, break, or chew it.
  • Common Brand Names: The combination is available under various brand names, including Istavel D, Dapaglyn S, and Sitadapa. 
Important Considerations and Side Effects
  • Do Not Stop Abruptly: Do not stop taking this medication without consulting your doctor, even if you feel better, as this can cause blood sugar levels to rise and increase the risk of serious complications.
  • Hypoglycemia Risk: The risk of low blood sugar (hypoglycemia) is higher when used with other antidiabetic medicines (like insulin or sulfonylureas) or alcohol. Always carry a quick source of sugar (e.g., candy or fruit juice) in case symptoms occur.
  • Hydration: Dapagliflozin can cause your body to lose too much fluid (dehydration) or make you urinate more often, so it is important to drink plenty of water and stay hydrated.
  • Hygiene: Good personal hygiene practices are essential as dapagliflozin can cause genital fungal and/or urinary tract infections (UTIs).
  • Avoid Alcohol: Alcohol consumption should be avoided or limited as it can increase the risk of serious side effects like ketoacidosis.
  • Potential Side Effects:
    • Genital yeast infections
    • Urinary tract infections (UTIs)
    • Headache
    • Nasopharyngitis (sore throat and runny nose)
    • Nausea and/or diarrhea
    • Joint pain 
Consult a healthcare professional if you experience any severe or persistent side effects, or if you have a history of heart, liver, or kidney disease before starting this medication. 

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